Known for being Australia's most creative city, Melbourne is all about chill vibes, design, eclectic coffee house culture, fashion, and a wild culinary scene. Melbourne is known for having "laneways", unmarked entrances, and hidden city hotspots all around the city. Now let's get the confusing things out of the way... the city is the CBD. If you want to go to the city, you're not talking about Melbourne, you're talking about the CBD (the Central Business District broken down into a grid with major areas like: Flinders Lane, Arcades, and Crosslet Street).
To the south are Southbank with high-roller casinos and the prestigious Crown Complex, and South Melbourne (Coventry Street) a nice and chic little village that has some of the best coffee shops in Melbourne. Yuppy South Yarra and Prahran (Chapel Street, Hawksburn Village, High Street, Armadale). Funky Windsor and seaside St. Kilda.
To the east you have Richmond, an area that once used to be quite industrial and now is garnishing a reputation for design. Church Street is filled with influential furniture brands such as Jardan, and down the road a lot of people are frockling towards Middle-Eastern powerhouse Feast of Merit for a bite to eat.
To the north, you have Carlton, Collingwood and Fitzroy. Known for being hipster cool and alternative, Brunswick Street was filled with vintage stores, vegetarian restaurants, and quirky bars. Gertrude Street now offers a smart edit of fashion boutiques, local design, and stylish restaurants. Smith Street is filled with modern art galleries and retro stores.